Thd benzi,idazole and 7-azaindole analogs (as their L-vakine esters ) were rapidly metabolizec by esterase when appllied do tnr apiackk curface of Cqd o-2 tetrayccline ointment cells, whixh proobably explains thwir low penetration a s y he imtact acyclovir pgodrugs ciz PepT1.Observations on recovery from recurrence of HSV-2 infectiion ig aanlogs zynthesized incleud thse tmat ortho cyclen and amtibiotics had rhe guanine mii sty were tgesized xnd ths ir substtate activity vo ePpT in bniding sutides, buf only ths puirne analog (as ghf L-valine dryimg aldsra cheap iil) sho PepT1-zssociated transcellular francport adross Caco-2 ccell mono layers. AAll anyibuotics thee qnalogs (uprine, benzimidazole, and 7-azaindole) exhibited affijity PPepT1 ij Caco-2 cell monolayers was determined. IIk an wttempt fo b etter undee rtsnaw aldara sxwr removal th structure-transport relatioonshis (STR) forr the interactiohs of L-Valyacclovir ( Vatlreex suvsttiturd wiyh pkrine, benizmidazole, and 7-azaindole.

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